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KMID : 0613820100200091420
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Journal of Life Science
2010 Volume.20 No. 9 p.1420 ~ p.1425
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Roles of Mannose-Binding Lectin on Innate Immunity and Disease
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Jang Ho-Jung
Park Jeong-Hae
Chung Kyung-Tae
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Abstract
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Innate immunity is the first line of host defense consisting of various molecules against infectious challenges. Mannose-binding lectin (MBL) belongs to the collectin protein family which takes part of innate immunity and is able to recognize specific carbohydrates on the surface of a variety of infectious agents acting as a pattern recognition molecule. In this way, MBL differentiates self from non-self and interacts with other molecules of the immune system. MBL genotype shows various MBL2 polymorphisms which are responsible for MBL deficiency in a substantial portion of the entire human population and for susceptibility to infectious disease. Therefore, it has been highlighted in the relationship between genetic variants and clinical significance. Here we focus on presenting anoverview of our understanding of MBL structure and functions.
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KEYWORD
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Mannose-binding lectin, innate immunity, C-type lectin, infectious disease
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